This project takes advantage of the scientific expertise of five research laboratories to understand and manipulate the cells and substances found in lymphoid tissue of patients with chronic lymphocytic leukemia (CLL). Cells of the myelomonocytic lineage and the T-cell lineage, in addition to CLL B cells themselves, are being studied using multiple ex vivo, in vitro, and in vivo methods. The progress report below indicates the magnitude of cooperative interactions that take place among the groups. All of the studies have as their final goal the design of novel therapeutic strategies and agents that will be translated into clinical practice to develop a cure for this still largely incurable disease.
Participants working together on CLL-Stroma Interaction include: